4-Hydroxyphenylpyruvate dioxygenase
Cofactors used
What it does, reaction by reaction
Amino Acid Catabolism Overview (glucogenic vs. ketogenic amino acids; brief overview of branched-chain amino acid catabolism and phenylalanine/tyrosine catabolism as representative examples) Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion
4-Hydroxyphenylpyruvate + O₂ → homogentisate + CO₂
Converts 4-Hydroxyphenylpyruvate O2 into Homogentisate CO2
› Notes
4-Hydroxyphenylpyruvate dioxygenase catalyzes oxidative decarboxylation and rearrangement using Fe²⁺. This is an essentially irreversible oxidative step.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
-
1
N-(4-Hydroxyphenethyl)-(4E)-decenamide derived from natural phytochemical of Anacyclus root ameliorates diabetic retinopathy by inhibiting angiogenesis via PARK7.
Ma Y, Sun H, Ji Q, Liu H, Wang J, Liu Y, Han J. · 2026-07-07
unreviewed -
2
Heterologous expression of hydroxylase coupled with pathway optimization enables highly efficient ʟ-DOPA production in <i>Corynebacterium glutamicum</i>.
Jia M, Duan R, Jiang Y, Chu X, Wu X, Yang H, Ye B, Zhang B. · 2026-05-16
open access unreviewed -
3
Surveillance and biological characterization of H3 subtype avian influenza viruses in Eastern China.
Miao X, Zhao X, Zhang N, Yin Y, Xu X, Wang J, Chen S, Wu H, Peng D, Qin T, Liu X. · 2026-05-19
open access unreviewed -
4
Targeted drug delivery systems for cardiovascular disease treatment: principles, targeting strategies, and future prospects.
Shao X, Wen J, Yan Z, Su X, Lin W, Li H, Yin H, Wu S, Wang Y. · 2026-05-11
open access unreviewed -
5
Shikimate crosstalk enables record-level homogentisic acid production in <i>Yarrowia lipolytica</i>.
Xu C, Zhang W, Zhao Q, Lin X, Wang K, Wang M, Tan T. · 2026-04-15
open access unreviewed -
6
High pathogenicity of human adenovirus type 55 in adult males: a meta-analysis and phylogenetic study of HAdV-55 epidemics worldwide over the past six decades.
Luo W, Guo W, Li Y, Zhao C, Weng Z, Duan B, Wu J, Yu X, Chen Z, Seto D, Chodosh J, Liang W, Ou J, Zhang Q. · 2026-04-01
open access unreviewed -
7
Neonatal intensive care unit admission among infants born full-term to CDC's COVID-19 Vaccine Pregnancy Registry participants: A matched cohort study.
Zauche LH, Madni SA, Shay DK, Olson CK, Machefsky A, Godfred Cato SE, Sharma AJ. · 2026-03-03
open access unreviewed -
8
FDA-approved IMPDH inhibitors synergize with ribavirin to inhibit respiratory syncytial virus by interfering with purine <i>de novo</i> synthesis.
Hu H, Wang Q, Ai Q, Zhou P, He Y, Ye Z, Ma K, Zhou M, Huang S, Wang L, Qi N, Xiao G, Wang S. · 2026-03-17
cited 2× open access unreviewed -
9
Mucosal immunization with an adenoviral vector expressing a prefusogenic F protein protects the upper and lower respiratory tracts of cotton rats against live respiratory syncytial virus challenge.
Mu T, Wang S, Ma T, Xu L, Xie L, Zhang Y, Sun B, Bao J, Wang Q, Klein M, Lu S, Wu K. · 2026-02-06
open access unreviewed -
10
Dual agonism and selective T-cell depletion activity of a PD-1-directed antibody for treating autoimmune diseases.
Jiang W, Li L, Xue W, He X, Chu X, Song L, Li X, Zhao R, Yuan X, Jin X, Fan L, Sun T, Zhu A, Zhou L, Gu F, Xu… · 2026-02-04
cited 1× open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.