4-Hydroxyphenylpyruvate dioxygenase
Cofactors used
What it does, reaction by reaction
Amino Acid Catabolism Overview (glucogenic vs. ketogenic amino acids; brief overview of branched-chain amino acid catabolism and phenylalanine/tyrosine catabolism as representative examples) Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion
4-Hydroxyphenylpyruvate + O₂ → homogentisate + CO₂
Converts 4-Hydroxyphenylpyruvate O2 into Homogentisate CO2
› Notes
4-Hydroxyphenylpyruvate dioxygenase catalyzes oxidative decarboxylation and rearrangement using Fe²⁺. This is an essentially irreversible oxidative step.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Metabolic engineering of <i>Escherichia coli</i> for efficient production of d-phenylglycine.
Xiong Y, Shang Z, Lu L, Wang T, Cai G, Shen X, Sun X, Wang J, Yuan Q. · 2026-08-07
open access unreviewed -
2
Transient culture of adult human hepatocytes as organoids improves engineered liver engraftment.
Saxton SH, Kang I, Mitchell S, Lotto J, Upadhyay A, Zou C, Quirk C, McCray TN, Prado O, Johansson F, Fortin C… · 2026-07-23
open access unreviewed -
3
Benzothiazole derivatives target oligoadenylate synthetase and enhance RSV vaccine efficacy as adjuvants.
Jin X, Zhang Z, Liu H, Tan Y, Luo P, Wen Z, Chen H, Liu L, Chen Y. · 2026-08-04
open access unreviewed -
4
N-(4-Hydroxyphenethyl)-(4E)-decenamide derived from natural phytochemical of Anacyclus root ameliorates diabetic retinopathy by inhibiting angiogenesis via PARK7.
Ma Y, Sun H, Ji Q, Liu H, Wang J, Liu Y, Han J. · 2026-07-07
unreviewed -
5
The evolutionary dynamics of human influenza B virus in Bangladesh, 2007-2025.
Islam S, Hasan M. · 2026-09-06
open access unreviewed -
6
Psychotic depression associated with Graves' disease: A case report on treatment prioritization.
Kocha A, Akaba A, Sawasaki N, Seno S, Hara N, Minato T, Nakagawa A, Kocha H. · 2026-09-30
open access unreviewed -
7
Nirsevimab for respiratory syncytial virus prevention: A comprehensive product review.
Razzini JL, Martinon-Torres F. · 2026-09-03
open access unreviewed -
8
Photodynamic antimicrobial and antineoplastic therapy in veterinary medicine: current status, challenges, and perspectives.
Lu J, Zhu S, Shaukat A, Bian S, Shi X, Zhu D, Wang J, Li A, Dai H, Liu F, Dong H, Zhang X. · 2026-08-16
open access unreviewed -
9
Development of tetrahydroquinazoline compounds as Fusion protein inhibitors for the treatment of respiratory syncytial virus.
Zhang H, Li Z, Zhou H, Jin G, You C, Zaman MK, He F, Wu Q, Liu N, Zhang J, Zhou Y, Li Y, Yang Z. · 2026-08-07
unreviewed -
10
Best evidence summary of exercise rehabilitation in patients undergoing pancreaticoduodenectomy.
He Y, Song P, Li L, Ye T. · 2026-07-04
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.