ER sterol-conversion enzyme series (19-step lanosterol->cholesterol)
What it does, reaction by reaction
Cholesterol Biosynthesis (Mevalonate Pathway) Lipid Metabolism · Cytosol + ER
Lanosterol → zymosterol/intermediate sterols → cholesterol
Converts Lanosterol
› Notes
A series of ER enzymes removes three methyl groups, reduces double bonds, and rearranges the sterol skeleton. Key human enzymes include lanosterol 14α-demethylase (CYP51A1), sterol C4-methyl oxidase complex, sterol Δ14-reductase (TM7SF2/LBR), sterol Δ8–Δ7 isomerase (EBP), sterol C5-desaturase (SC5D), and 24-dehydrocholesterol reductase (DHCR24) or 7-dehydrocholesterol reductase (DHCR7), depending on the terminal route. These oxygenase/reductase reactions require molecular oxygen and reducing equivalents, chiefly NADPH; the overall pathway is effectively irreversible.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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