Dihydroorotate dehydrogenase (DHODH)
Cofactors used
Clinical / pharmacological. Target of leflunomide/teriflunomide; only mitochondrial step of pyrimidine synthesis
What it does, reaction by reaction
Pyrimidine De Novo Synthesis (through to UMP, then CTP/dTMP) Nucleotide Metabolism · Cytosol (one mitochondrial step)
Dihydroorotate → orotate
Converts Dihydroorotate into Orotate
› Notes
DHODH catalyzes L-dihydroorotate + ubiquinone (CoQ) → orotate + ubiquinol (CoQH2). Flavin mononucleotide (FMN) is the redox cofactor; mitochondrial electron transport regenerates oxidized CoQ. This is the only mitochondrial-associated step of the pathway.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Research progress of ferroptosis in gynecological diseases.
Chen W, Zhou W, Liu S. · 2026-06-19
open access unreviewed -
2
IGF2BP3 promotes gastric cancer progression by inhibiting ferroptosis through ETV4-mediated regulation of GCH1.
Li K, Wei H, Li F, Zheng Y, Zhou Y. · 2026-05-01
open access unreviewed -
3
PROTACs in cancer therapy: targeted degradation of GPX4, PARP and epigenetic regulators.
Periyasamy S, Jarrett T, Truong J, Skouta R. · 2026-03-26
open access unreviewed -
4
FDA-approved IMPDH inhibitors synergize with ribavirin to inhibit respiratory syncytial virus by interfering with purine <i>de novo</i> synthesis.
Hu H, Wang Q, Ai Q, Zhou P, He Y, Ye Z, Ma K, Zhou M, Huang S, Wang L, Qi N, Xiao G, Wang S. · 2026-03-17
cited 2× open access unreviewed -
5
Antitumor activity and structure-activity relationship of poly (ADP-ribose) polymerase (PARP)-based dual inhibitors.
Yang C, Shang Y, Li X, Li J, Li H, Han J. · 2025-12-15
open access unreviewed -
6
Ubiquitination-dependent regulation of ferroptosis in ischemic heart and brain.
Zhang YY, Long XY, Tian J, Luo XJ, Peng J. · 2026-06-08
open access unreviewed -
7
Ferroptosis and prostate cancer: A translational path from molecular mechanisms to precision therapy.
Huang Y, Ma Y, He J, Song T. · 2025-12-08
open access unreviewed -
8
Contribution of dihydroorotate dehydrogenase complex to NADH supply and metabolic flux redirection in Clostridium acetobutylicum.
Jiang D, Yi J, Zhu H, Gao L, Wang S, Liu G, Li L, Zhang Q, Wang M, Ehrenheich A, Li F, Xiao Y, Liu Z, Zhang K. · 2026-05-25
unreviewed -
9
Targeting dihydroorotate dehydrogenase (hDHODH) beyond the barrier: discovery of MEDS700 as blood-brain barrier permeable hDHODH inhibitor.
Sainas S, Vigato C, Circosta P, Zonfrillo M, Servidei T, Alberti M, Rescigno M, Miggiano R, Gaidano V, Vitale… · 2026-04-27
unreviewed -
10
Novel noscapine derivative induces AML differentiation by dual-engaging DHODH and mitochondrial lipids to trigger a metabolic-epigenetic-transcriptional cascade.
Shen S, Li D, Zhang Y, Li S, Li L, Shen W, Ma Y, Zhang W, Tao R, Wang W, Jiang B, Bai F, Liu C, Zhang Y, Yin … · 2026-05-22
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.