What it does, reaction by reaction
Sphingolipid Synthesis Lipid Metabolism · ER + Golgi
Dihydroceramide -> ceramide
Converts Dihydroceramide into Ceramide
› Notes
Ceramide is the hub metabolite of all complex sphingolipids and a pro-apoptotic signal.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Single-cell RNA sequencing analysis of bone cancer pain model induced by Lewis lung cancer cells in male mice.
Zhou Q, Chen J, Wang H, Jin R, Paerhati H, Zhu X, Dong G, Zhang M, Jiang F. · 2026-02-27
cited 2× open access unreviewed -
2
Prevalence of Dyslipidemia and Associated Factors Among Adult Outpatients at Jimma Medical Center, Southwest Ethiopia: A Cross‐Sectional Study
Ashine A, Kero B, Gebremichael E, Dadigeba M, Geremamo Y, Dawud E, Birara E, Bejiga Y, Tafese S, Woyimo T. · 2026-10-01
open access unreviewed -
3
Identifying Co-Expressed lncRNAs Correlated With Traits of Interest in an Animal Model for Metabolic Diseases in Humans.
Nascimento LE, da Silva BPM, de Oliveira CS, Durval MC, Freitas FAO, Ciconello FN, Gervásio IC, Fanalli SL, d… · 2026-10-01
open access unreviewed -
4
Whole-exome sequencing reveals novel and previously reported variants in genes linked to white matter pathology in neurodevelopmental disorders.
Ahmad N, Aleem T, Liu C, Rashid M, Tehreem J, Junaid MAM, Asif MF, Ullah S, Ullah S, Afridi TUK, Baig UR, Tar… · 2026-07-09
cited 1× open access unreviewed -
5
Targeting the tumor microenvironment: a new strategy for natural products in breast cancer therapy.
Liu YC, Yang YR, Wang JL, Yu HY, Shao M, Zhou HF. · 2026-09-30
open access unreviewed -
6
A seven-gene signature associated with inner mitochondrial membrane protein-defined molecular subtypes for prognostic stratification in gastric cancer.
Yang G, Ma T, Yao L, Li Z, Yuan L, Wan D. · 2026-09-23
unreviewed -
7
Sphingolipid Remodeling and Extracellular Vesicle Signatures Reflect Disease Severity in Facioscapulohumeral Dystrophy Driven by Mitochondrial Dysfunction and Endoplasmic Reticulum Stress.
Moriggi M, Ruggiero L, Torretta E, Zoppi D, Arosio B, Fiorillo C, Nigro V, Capitanio D, Gelfi C. · 2026-09-14
open access unreviewed -
8
Ceramide synthesis mediates colorectal cancer metastasis through a YAP-driven regenerative program.
Goswami S, Zhang Q, Yildiz AB, Das Adhikari U, Raghawan AK, Bulliard M, Sedhain S, Darawshi O, Celik CE, Cans… · 2026-09-24
unreviewed -
9
Multi-omics profiling reveals sphingolipid metabolism reprogramming of tumor-conditioned MDSCs in cervical cancer.
Mai Q, Chi C, Wang X, Chen Y, Zou Q, Chen Q, Zeng F, Wei M, Chen Y, Wang A, Liao Y, Xiao Y, Li X, Yan Q, Zhan… · 2026-09-18
open access unreviewed -
10
Lifestyle factors and symptom burden in endometriosis: an exploratory mixed-methods analysis of nutrition, physical activity, and psychosocial well-being.
Wulfhorst L, Henze A, Portius D. · 2026-09-17
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.