Diacylglycerol acyltransferase (DGAT1 or DGAT2)
Cofactors used
What it does, reaction by reaction
Triacylglycerol Synthesis and Lipolysis Lipid Metabolism · Cytosol / ER
DAG + fatty acyl-CoA → TAG + CoA-SH
Converts Diacylglycerol Fatty acyl-CoA into Triacylglycerol (TAG) CoA-SH
› Notes
Diacylglycerol acyltransferase (DGAT1 or DGAT2) catalyzes the terminal acylation. This is the final committed step of TAG assembly; TAG is packaged into lipid droplets or, in liver/intestine, into apoB-containing lipoproteins.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Early postnatal antibiotic-associated gut microbiota alterations might promote long-term lipid metabolism via brown adipose tissue metabolic programming.
Liang H, Jiang F, Ren L, Li X, Wu S, Li J, Li L, Ze X, Shen X, He F. · 2026-05-04
open access unreviewed -
2
Annexin A1 exacerbates islet stellate cell activation by regulating triglyceride catabolism via the PPARα/ACOX1/CYP4a pathway.
Li Q, Zhang Y, Yu T, Shi L, Qiu Q, Wang B, Sang Y, Li R, Lv Q, Wang J, Liu X, Geng H, Jones PM, Liang J, Xu W. · 2026-02-22
open access unreviewed -
3
Diacylglycerol enantiomer selectivity of diacylglycerol acyltransferases highlights metabolic specialization in triacylglycerol synthesis across the tree of life.
Parchuri P, Shockey J, Durrett TP, Bates PD. · 2026-07-01
open access unreviewed -
4
Micro- and Nanoplastics as Emerging Drivers of Liver Injury: Exposure, Evidence, and Mechanisms
Badach M, Banaszek J, Barańska K, Kleinrok J, Flieger M, Flieger J, Teresiński G, Forma A, Sitarz R, Baj J. · 2026-06-01
open access unreviewed -
5
Fatty acid esters of hydroxy fatty acids and alkyl-diacylglycerols: minor but bioactive components in human milk.
Lee MLX, Elejalde U, Cazenave-Gassiot A. · 2026-06-01
open access unreviewed -
6
Hepatic Lipoprotein Production, Cardiometabolic Phenotypes, and Subtypes of Steatotic Liver Disease.
Davidson NO. · 2026-06-04
cited 1× unreviewed -
7
The mTOR-Dop1a-Agpat2 axis regulates nuclear phospholipid homeostasis.
Ariyama H, Tsukamura A, Miyatake S, Okado S, Itabashi I, Ogura A, Suzuki A, Kurakawa H, Sakaguchi Y, Nakatake… · 2026-04-22
open access unreviewed -
8
ACSS2 governs milk fat synthesis in buffalo via a reciprocal positive feedback loop with SREBP1 and PPARG.
Huang L, Wang R, Zhou F, Gao R, Fan X, Miao Y. · 2026-03-11
open access unreviewed -
9
Fatty acid in the intramuscular and abdominal fat of chickens: their composition, deposition, regulation and impact on flavor.
Zou J, Li H, Zhang X. · 2026-05-25
open access unreviewed -
10
Opposite diacylglycerol enantiomeric specificities of Arabidopsis DGAT1 and DGAT2 reveal distinct roles in TAG synthesis.
Jaison CA, Björklund J, Stymne S, Demski K, Hofvander P, Lager I. · 2026-05-01
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.