Diacylglycerol acyltransferase (DGAT1 or DGAT2)
Cofactors used
What it does, reaction by reaction
Triacylglycerol Synthesis and Lipolysis Lipid Metabolism · Cytosol / ER
DAG + fatty acyl-CoA → TAG + CoA-SH
Converts Diacylglycerol Fatty acyl-CoA into Triacylglycerol (TAG) CoA-SH
› Notes
Diacylglycerol acyltransferase (DGAT1 or DGAT2) catalyzes the terminal acylation. This is the final committed step of TAG assembly; TAG is packaged into lipid droplets or, in liver/intestine, into apoB-containing lipoproteins.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Early postnatal antibiotic-associated gut microbiota alterations might promote long-term lipid metabolism via brown adipose tissue metabolic programming.
Liang H, Jiang F, Ren L, Li X, Wu S, Li J, Li L, Ze X, Shen X, He F. · 2026-05-04
open access unreviewed -
2
Annexin A1 exacerbates islet stellate cell activation by regulating triglyceride catabolism via the PPARα/ACOX1/CYP4a pathway.
Li Q, Zhang Y, Yu T, Shi L, Qiu Q, Wang B, Sang Y, Li R, Lv Q, Wang J, Liu X, Geng H, Jones PM, Liang J, Xu W. · 2026-02-22
open access unreviewed -
3
Inhibiting menin attenuates high-fat diet-induced weight gain by limiting intestinal lipid absorption in mice.
Cao X, Zhou P, Meng H, Guo Z, Cao Y, Wang C, Liu L, Guo Y, Wang Y, Xin G, Liu D, Geng F, Ma J. · 2026-08-11
open access unreviewed -
4
Mutual antagonism between auxin and diacylglycerol acyltransferase 2 regulates high-temperature-induced hypocotyl elongation.
Khamzaaliyeva M, Lalchand P, Ashley DD, Pan X. · 2026-08-09
open access unreviewed -
5
Bovine viral diarrhea virus (BVDV) relies on cellular lipid droplet biogenesis and lipolysis to provide energy for viral replication.
Xiong X, Liu Y, Zhu Y, Wang J, Yang G. · 2026-09-19
open access unreviewed -
6
COL1A1-Enhanced CD44/SLC7A11 Interaction and Cystine Uptake Result in CD34<sup>+</sup> Foam-Like Macrophage Accumulation in Transplant Arteriosclerosis.
Wu J, He T, Qi M, Chen L, Yao M, Zhao X, Zhou Q, Zhang W, Huang X, Liu Y, Gong Y, Shi T, Hong Y, Gao H, Weng … · 2026-08-04
open access unreviewed -
7
A hickory diacylglycerol acyltransferase gene coordinates fatty acid metabolism and aluminum tolerance in plants.
Zheng S, Chen W, Zhang J, Wang F, Zhao J, Zhang B, Zhou X, Zhang Q, Wu J, Lou H. · 2026-07-12
unreviewed -
8
Fatty acid in the intramuscular and abdominal fat of chickens: their composition, deposition, regulation and impact on flavor.
Zou J, Li H, Zhang X. · 2026-05-25
open access unreviewed -
9
Remodeling of leaf lipidome during cold acclimation, de-acclimation, and re-acclimation influences frost tolerance of Festuca arundinacea.
Górna J, Perlikowski D, Alseekh S, Rapacz M, Fernie AR, Wójcik-Jagła M, Kosmala A. · 2026-09-01
open access unreviewed -
10
Triacylglycerol synthesis in microalgae under abiotic stress: an updated integrative review.
Bhatnagar VS, Saldat M, Zienkiewicz A, Du ZY, Zienkiewicz K. · 2026-09-01
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.