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unreviewed

Deoxycytidine kinase (dCK) / deoxyguanosine kinase (dGK)

2 reactions · 1 pathways

Cofactors used

ATP

What it does, reaction by reaction

2 reactions

Purine Salvage Pathway Nucleotide Metabolism · Cytosol

step 7 Irreversible/directional

Deoxyadenosine → deoxyadenosine monophosphate (dAMP)

Converts Deoxyadenosine into Deoxyadenosine monophosphate

› Notes

Deoxycytidine kinase (dCK) and, in selected tissues, deoxyguanosine kinase (dGK) can phosphorylate deoxyadenosine using ATP: deoxyadenosine + ATP → dAMP + ADP. These nucleoside kinases are especially relevant to deoxynucleoside salvage and activation of nucleoside analog drugs; dGK is mitochondrial, whereas dCK is cytosolic/nuclear.

step 8 Irreversible/directional

Deoxyguanosine → deoxyguanosine monophosphate (dGMP)

Converts Deoxyguanosine into Deoxyguanosine monophosphate

› Notes

dCK (and mitochondrial dGK where expressed) catalyzes deoxyguanosine + ATP → dGMP + ADP. Subsequent nucleoside monophosphate and diphosphate kinases generate dGDP and dGTP.

Showing all 2 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Roles of nucleotide metabolism in pancreatic cancer.

    Liu Q, Liu J, Wang S, Bao N, Zhao X, Wang L. · 2025-10-22

    open access unreviewed
  2. 2
    Understanding the interplay between dNTP metabolism and genome stability in cancer.

    Yagüe-Capilla M, Rudd SG. · 2024-08-29

    cited 16× open access unreviewed
  3. 3
    SAMHD1 is a key regulator of the lineage-specific response of acute lymphoblastic leukaemias to nelarabine.

    Rothenburger T, McLaughlin KM, Herold T, Schneider C, Oellerich T, Rothweiler F, Feber A, Fenton TR, Wass MN,… · 2020-06-24

    cited 27× open access unreviewed
  4. 4
    An efficient proteome-wide strategy for discovery and characterization of cellular nucleotide-protein interactions.

    Lim YT, Prabhu N, Dai L, Go KD, Chen D, Sreekumar L, Egeblad L, Eriksson S, Chen L, Veerappan S, Teo HL, Tan … · 2018-12-06

    cited 48× open access unreviewed
  5. 5
    New Variants of Tomato Thymidine Kinase 1 Selected for Increased Sensitivity of E. coli KY895 towards Azidothymidine.

    Christiansen LS, Egeblad L, Munch-Petersen B, Piškur J, Knecht W. · 2015-06-08

    cited 3× open access unreviewed
  6. 6
    DNA repair mechanisms in cancer development and therapy.

    Torgovnick A, Schumacher B. · 2015-04-23

    cited 258× open access unreviewed
  7. 7
    Novel leukemic cell lines resistant to clofarabine by mechanisms of decreased active metabolite and increased antiapoptosis.

    Shigemi H, Yamauchi T, Tanaka Y, Ueda T. · 2013-04-03

    cited 9× unreviewed
  8. 8
    Transgene expression of Drosophila melanogaster nucleoside kinase reverses mitochondrial thymidine kinase 2 deficiency.

    Krishnan S, Zhou X, Paredes JA, Kuiper RV, Curbo S, Karlsson A. · 2013-01-03

    cited 11× unreviewed
  9. 9
    Real-time quantitative PCR assays for deoxycytidine kinase, deoxyguanosine kinase and 5'-nucleotidase mRNA measurement in cell lines and in patients with leukemia.

    Månsson E, Liliemark E, Söderhäll S, Gustafsson G, Eriksson S, Albertioni F. · 2002-03-01

    cited 13× unreviewed
  10. 10
    Novel deoxynucleoside-phosphorylating enzymes in mycoplasmas: evidence for efficient utilization of deoxynucleosides.

    Wang L, Westberg J, Bölske G, Eriksson S. · 2001-11-01

    cited 41× unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.