Deoxycytidine kinase (dCK) / deoxyguanosine kinase (dGK)
Cofactors used
What it does, reaction by reaction
Purine Salvage Pathway Nucleotide Metabolism · Cytosol
Deoxyadenosine → deoxyadenosine monophosphate (dAMP)
Converts Deoxyadenosine into Deoxyadenosine monophosphate
› Notes
Deoxycytidine kinase (dCK) and, in selected tissues, deoxyguanosine kinase (dGK) can phosphorylate deoxyadenosine using ATP: deoxyadenosine + ATP → dAMP + ADP. These nucleoside kinases are especially relevant to deoxynucleoside salvage and activation of nucleoside analog drugs; dGK is mitochondrial, whereas dCK is cytosolic/nuclear.
Deoxyguanosine → deoxyguanosine monophosphate (dGMP)
Converts Deoxyguanosine into Deoxyguanosine monophosphate
› Notes
dCK (and mitochondrial dGK where expressed) catalyzes deoxyguanosine + ATP → dGMP + ADP. Subsequent nucleoside monophosphate and diphosphate kinases generate dGDP and dGTP.
Showing all 2 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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