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unreviewed

Deoxycytidine kinase (dCK)

1 reactions · 1 pathways

Cofactors used

ATP

What it does, reaction by reaction

1 reactions

Deoxyribonucleotide Formation (Ribonucleotide Reductase pathway and thymidylate synthesis) Nucleotide Metabolism · Cytosol

step 12 Irreversible/directional

Deoxycytidine or thymidine → dCMP or dTMP (salvage support)

Converts Deoxycytidine Thymidine into dCMP dTMP

› Notes

Cytosolic deoxycytidine kinase phosphorylates deoxycytidine + ATP → dCMP + ADP, while cytosolic thymidine kinase 1 phosphorylates thymidine + ATP → dTMP + ADP in S phase; mitochondrial thymidine kinase 2 supports mitochondrial dTTP supply in nondividing cells. These are salvage reactions, not de novo formation, but they can bypass part of the RNR/thymidylate pathway and materially affect dNTP homeostasis.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Targeting IMPDH to inhibit SAMHD1 in <i>KMT2A</i>-rearranged leukaemia.

    Klootsema Y, Tsesmetzis N, Sharma S, Hofmann S, Thier J, Dirks C, Hormann FM, Yagüe-Capilla M, Bohlin A, Beng… · 2025-12-15

    open access unreviewed
  2. 2
    Comorbidity Associations with Ocular Pain after Cataract Surgery: Overall and Sex-Stratified Analysis.

    Haddad EN, Amin RS, Sharma A, Zhao A, Kim SB, Kaelber DC, Singh RP, Talcott KE, Rotroff DM, Sayegh RR. · 2026-09-08

    unreviewed
  3. 3
    [The German Surgery Congress from the perspective of young surgeons; expectations and barriers : Results of a nationwide online survey].

    Schaaf S, Perspektivforum Junge Chirurgie der Deutschen Gesellschaft für Chirurgie, Brunner S, Chirurgische A… · 2026-08-12

    open access unreviewed
  4. 4
    Folic acid alleviates neuroinflammation after intracerebral hemorrhage by epigenetically regulating the AMPD2/DCK/NF-κB pathway.

    Xu Y, Hu J, Wu M, Yang J, Dai Z, Xu T, Gao X, Huang Y, Zhou S. · 2026-07-24

    unreviewed
  5. 5
    ADAMTS14 is a novel modulator of fibroblast mechanoactivation in pulmonary fibrosis.

    Ganzleben I, Jaiswal A, Yang Y, Santos DM, Segal A, McCabe MC, Medina EM, Reynolds G, Zhang J, Yun SH, Krug T… · 2026-10-01

    open access unreviewed
  6. 6
    Anthelmintic stewardship: An essential step towards sustainable dairy farming.

    Bijkerk HJC, Antonis AFG, Wagenaar JA, Lam TJGM, van Doorn DCK. · 2026-07-03

    unreviewed
  7. 7
    From Marginal to Central: Marginal Zone-like B Cells as Critical Targets in Cladribine-Treated Multiple Sclerosis.

    Pirronello M, Picozza M, Guerrera G, Corbisiero S, Misiti A, Placido RC, Verdiani A, de Marco L, Sambucci M, … · 2026-06-18

    cited 1× open access unreviewed
  8. 8
    Pharmacogenomic profiling of the efficacy of gemcitabine monotherapy in metastatic pancreatic cancer: Subgroup analysis of the GENESECT study.

    Yokokawa T, Tsuji D, Hatori M, Kawakami K, Nakao M, Yano T, Arakawa Y, Matsuo K, Ohashi Y, Ozaka M, Sasahira … · 2026-06-01

    open access unreviewed
  9. 9
    Risk-Aware Fault-Tolerant Multisensor Fusion for Human-Machine Decision Support in Autonomous Navigation and Mooring in Confined Waters.

    Kondratyev SI, Khekert EV, Martyushev NV, Malozyomov BV, Kukartsev VV, Tynchenko VV, Panfilova TA, Tynchenko … · 2026-09-08

    open access unreviewed
  10. 10
    Chromosomal Heterogeneity and Enrichment of Mitotic Regulatory Programs Reveal a Therapeutic Vulnerability in Cytarabine-Resistant FLT3-ITD AML.

    Yen JH, Chen ZA, Lin YX, Jiang HY, Lin LI, Li CC, Chen PY. · 2026-09-21

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.