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unreviewed

Deoxycytidine kinase (dCK)

1 reactions · 1 pathways

Cofactors used

ATP

What it does, reaction by reaction

1 reactions

Deoxyribonucleotide Formation (Ribonucleotide Reductase pathway and thymidylate synthesis) Nucleotide Metabolism · Cytosol

step 12 Irreversible/directional

Deoxycytidine or thymidine → dCMP or dTMP (salvage support)

Converts Deoxycytidine Thymidine into dCMP dTMP

› Notes

Cytosolic deoxycytidine kinase phosphorylates deoxycytidine + ATP → dCMP + ADP, while cytosolic thymidine kinase 1 phosphorylates thymidine + ATP → dTMP + ADP in S phase; mitochondrial thymidine kinase 2 supports mitochondrial dTTP supply in nondividing cells. These are salvage reactions, not de novo formation, but they can bypass part of the RNR/thymidylate pathway and materially affect dNTP homeostasis.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Targeting IMPDH to inhibit SAMHD1 in <i>KMT2A</i>-rearranged leukaemia.

    Klootsema Y, Tsesmetzis N, Sharma S, Hofmann S, Thier J, Dirks C, Hormann FM, Yagüe-Capilla M, Bohlin A, Beng… · 2025-12-15

    open access unreviewed
  2. 2
    [The German Surgery Congress from the perspective of young surgeons; expectations and barriers : Results of a nationwide online survey].

    Schaaf S, Perspektivforum Junge Chirurgie der Deutschen Gesellschaft für Chirurgie, Brunner S, Chirurgische A… · 2026-08-12

    unreviewed
  3. 3
    Folic acid alleviates neuroinflammation after intracerebral hemorrhage by epigenetically regulating the AMPD2/DCK/NF-κB pathway.

    Xu Y, Hu J, Wu M, Yang J, Dai Z, Xu T, Gao X, Huang Y, Zhou S. · 2026-07-24

    unreviewed
  4. 4
    Anthelmintic stewardship: An essential step towards sustainable dairy farming.

    Bijkerk HJC, Antonis AFG, Wagenaar JA, Lam TJGM, van Doorn DCK. · 2026-07-03

    unreviewed
  5. 5
    Emerging new psychoactive ketamine analogues: patterns of use and health risks identified by the French Addictovigilance Network.

    Mezaache S, Pochard L, Peyrière H, Fouilhé Sam-Laï N, Micallef J. · 2026-05-05

    unreviewed
  6. 6
    Challenges in tracer development for tumor microenvironment (TME) imaging.

    Martin S, Wendlinger L, Koch H, Lopez-Martinez I, Corsanici G, Battistini G, Bonvin Y, Delage J, Viertl D, Fa… · 2026-04-10

    open access unreviewed
  7. 7
    Adaptive Regulation of dNTP Homeostasis Confers Osimertinib Resistance in EGFR-Mutant Non-Small Cell Lung Carcinoma.

    Xie Q, Wang Y, Fernandez A, Lei Y, Gong Y, Hess JD, Yang L, Xin D, Williams TM, Zheng L, Shen B, Li M. · 2026-07-01

    open access unreviewed
  8. 8
    Metabolic and Molecular Mechanisms of Gemcitabine Resistance in Urothelial Carcinoma.

    Yamashita T, Nagamoto S, Arai M, Kitayama S, Yano A, Higashi M. · 2026-06-30

    unreviewed
  9. 9
    Prenatal Spectrum of COL2A1-Related Spondyloepiphyseal Dysplasia Congenita: A Review and Two Case Reports.

    Larissa LR, Felipe LL, Salvador JC, Manuel GJ, Jose RM, Angelica CD, Alejandra DCK, Lucia YA, Valeria MD, Jes… · 2026-06-26

    unreviewed
  10. 10
    Family-Based Study Reveals PDE11A/PDE11A-AS1 Variants in Testicular Germ Cell Tumor Predisposition

    Côrtes L, Rodrigues A, Silveira S, Ramírez-Mejía J, Dreyer C, Aagaard M, Fernandez G, Lopes A, Filho J, Rogat… · 2026-06-01

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.