What it does, reaction by reaction
Deoxyribonucleotide Formation (Ribonucleotide Reductase pathway and thymidylate synthesis) Nucleotide Metabolism · Cytosol
Deoxycytidine or thymidine → dCMP or dTMP (salvage support)
Converts Deoxycytidine Thymidine into dCMP dTMP
› Notes
Cytosolic deoxycytidine kinase phosphorylates deoxycytidine + ATP → dCMP + ADP, while cytosolic thymidine kinase 1 phosphorylates thymidine + ATP → dTMP + ADP in S phase; mitochondrial thymidine kinase 2 supports mitochondrial dTTP supply in nondividing cells. These are salvage reactions, not de novo formation, but they can bypass part of the RNR/thymidylate pathway and materially affect dNTP homeostasis.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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