D-beta-hydroxybutyrate dehydrogenase (BDH1)
Cofactors used
What it does, reaction by reaction
Ketogenesis Lipid Metabolism · Liver mitochondrial matrix
Acetoacetate + NADH + H+ ⇌ D-β-hydroxybutyrate + NAD+
Converts Acetoacetate NADH H+ into D-beta-hydroxybutyrate NAD+
› Notes
Mitochondrial D-β-hydroxybutyrate dehydrogenase interconverts the two principal ketone bodies. The mitochondrial NADH/NAD+ ratio determines their ratio: high NADH generated by β-oxidation favors D-β-hydroxybutyrate.
Ketolysis (Ketone Body Utilization) Lipid Metabolism · Mitochondrial matrix
D-β-hydroxybutyrate + NAD+ → acetoacetate + NADH + H+
Converts D-beta-hydroxybutyrate NAD+ into Acetoacetate NADH H+
› Notes
Mitochondrial D-β-hydroxybutyrate dehydrogenase oxidizes D-β-hydroxybutyrate to acetoacetate. This produces one NADH, and the reaction direction in extrahepatic tissue is favored by the local mitochondrial redox state.
Showing all 2 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Development and validation of a digital PCR assay targeting plasma <i>FAR1</i> methylation for early detection of hepatocellular carcinoma.
Park SJ, Lee YY, Chung YK, Jung BH, An J, Han J, Moon Y, Wang HJ. · 2026-04-20
open access unreviewed -
2
Research progress in metabolic reprogramming and targeting metabolic pathways for clear cell renal cell carcinoma.
Yao JT, Hu PC, Li XW, Xu JC, Wang KJ, Ye SZ, Meng XY, Chen HC, Liang Y, Ma Q. · 2025-12-19
open access unreviewed -
3
Sotagliflozin Reprograms Hepatic Lipid Metabolism and Attenuates Atherosclerosis Beyond Empagliflozin in CKM Mice
· 2026-10-01
open access unreviewed -
4
From Genomics to Precision Cardiology: A Comprehensive Review of Clinical Applications and Challenges in Cardiovascular Diseases.
Mohsen-Pour N, Esmaeili S, Feyzi A, Sharafi A, Maleki M, Kalayinia S. · 2026-10-01
open access unreviewed -
5
Dapagliflozin ameliorates pulmonary arterial hypertension-induced right heart failure via ketone body metabolism and mitochondrial function enhancement.
Xu W, Liu J, Yan L, Er L, Tian S, Du R. · 2026-09-03
unreviewed -
6
Murine metabolic HFpEF is associated with altered mitochondrial substrate handling and S-nitrosylation remodeling.
Li H, Cui H, Wang D, Leuschner F, Heineke J, Hu J, Bibli SI. · 2026-08-12
open access unreviewed -
7
Mitochondria-to-plasma-membrane H<sub>2</sub>O<sub>2</sub> signaling induced by branched-chain keto acid oxidation essentially stimulates insulin secretion in pancreatic β-cells.
Klöppel E, Engstová H, Duspiva P, Tauber J, Mozheitova O, Jabůrek M, Ježek P. · 2026-07-16
open access unreviewed -
8
Neuropathology of Friedreich ataxia and its links to metabolic pathways.
Mercado-Ayón E, Lazaropoulos MP, Mercado-Ayón Y, Lynch DR. · 2025-12-25
cited 2× open access unreviewed -
9
White Adipose Tissue Contributes to Cardiac Homeostasis and Adaptation to Cardiometabolic Stress in a Sex- and Depot-Specific Manner.
Thibodeau SÈ, Le Bos N, Walsh-Wilkinson É, Labbé EA, Morin-Grandmont A, Trahan E, Zakrzewski M, Couet J. · 2026-09-19
open access unreviewed -
10
Combined Analysis of Transcriptome and Metabolome of Large-Size Triploid Rainbow Trout in Different Seasons.
Li Z, Li C, Jin W, Liang T, Huang S, Zhang J, Xie X, Chen Y. · 2026-09-20
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.