D-beta-hydroxybutyrate dehydrogenase (BDH1)
Cofactors used
What it does, reaction by reaction
Ketogenesis Lipid Metabolism · Liver mitochondrial matrix
Acetoacetate + NADH + H+ ⇌ D-β-hydroxybutyrate + NAD+
Converts Acetoacetate NADH H+ into D-beta-hydroxybutyrate NAD+
› Notes
Mitochondrial D-β-hydroxybutyrate dehydrogenase interconverts the two principal ketone bodies. The mitochondrial NADH/NAD+ ratio determines their ratio: high NADH generated by β-oxidation favors D-β-hydroxybutyrate.
Ketolysis (Ketone Body Utilization) Lipid Metabolism · Mitochondrial matrix
D-β-hydroxybutyrate + NAD+ → acetoacetate + NADH + H+
Converts D-beta-hydroxybutyrate NAD+ into Acetoacetate NADH H+
› Notes
Mitochondrial D-β-hydroxybutyrate dehydrogenase oxidizes D-β-hydroxybutyrate to acetoacetate. This produces one NADH, and the reaction direction in extrahepatic tissue is favored by the local mitochondrial redox state.
Showing all 2 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Development and validation of a digital PCR assay targeting plasma <i>FAR1</i> methylation for early detection of hepatocellular carcinoma.
Park SJ, Lee YY, Chung YK, Jung BH, An J, Han J, Moon Y, Wang HJ. · 2026-04-20
open access unreviewed -
2
Redox coupling of lactate and β-hydroxybutyrate: An inter-organ circuit linking metabolic flexibility, mitochondrial adaptation, and disease.
Lin D, Qiu X, Wang Y, Xiang Y, Huang C. · 2026-06-26
unreviewed -
3
Acetoacetyl-CoA synthetase modulates lipid partitioning and cholesterol-related gene expression in NEFA-challenged neonatal bovine hepatocytes.
Tian Y, Wang S, Loor JJ, Fan W, Chang Y, Yang T, Zhang B, Xia C, Xu C, Li X, Yang W. · 2026-05-11
unreviewed -
4
Empagliflozin Reduces Post-Myocardial Infarction Inflammation via BDH1/β-Hydroxybutyrate-Mediated NF-κB Modulation in Macrophages and the Heart.
Yang J, Meng K, Wu G, Liang J, Lin J, Huang R, Zhang J, Li D, Kong X, Su H, Zhang F, Ge J. · 2026-08-12
unreviewed -
5
High-fat, low-carb diet reduces tumor growth and induces liver metabolism remodeling in a breast cancer mouse model.
Charlot A, Bringolf A, Mallard J, Jaulin A, Crouchet E, Duteil D, Alpy F, Tomasetto CL, Baumert TF, Zoll J. · 2026-06-16
unreviewed -
6
Intracellular microbial shifts during COVID-19 infection and longitudinal recovery revealed by single-cell RNA sequencing.
Soni J, Ali R, Chattopadhyay P, Devi P, Mehta P, Yadav A, Jaiswal A, Tarai B, Budhiraja S, Pandey R. · 2026-06-11
open access unreviewed -
7
Impaired Lung BCAA Metabolism Promotes Ferroptosis and Resultant Pulmonary Arterial Hypertension-Associated Hepatopathy.
Blake MJ, Hong J, Brownstein A, Rhodes CJ, Swietlik EM, Blake JC, Moon RA, Hartweck LM, Mendelson JB, Prisco … · 2026-05-30
open access unreviewed -
8
Lactylation landscape of mitochondrial proteins in myocardial infarction.
Kadam A, Kashyap S, Samantaray K, Jaiswal N, Goyani S, Kramer PA, Hadi P, Lee J, Furdui CM, Jadiya P, Tomar D. · 2026-05-18
open access unreviewed -
9
Cytosolic PRDX1 acts as an extramitochondrial sink to set mitochondrial H<sub>2</sub>O<sub>2</sub> levels and enable resilience to chronic mitochondrial oxidative stress.
Jacobs LJ, Doll S, Trümbach D, Veronese M, Di Pietro G, Yapici FI, Hasberg L, Gentzsch P, Gerlich S, Hansen J… · 2026-04-30
cited 1× open access unreviewed -
10
Cardioprotective Effects of 1,3 Butanediol in MASLD via Reversal of Cardiac Lipid Accumulation and Suppression of Cardiac Fibrosis
Badmus O, Parrow L, McGowen K, Bell L, Greer J, Cruz M, Hinds T, Stec D. · 2026-06-01
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.