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(acquired B1 deficiency) Acquired unreviewed

Wernicke-Korsakoff syndrome

PDC / TCA / PPP (thiamine) PDH, alpha-KG dehydrogenase, transketolase

Enzyme or protein defect

PDH, alpha-KG dehydrogenase, transketolase

Accumulates or becomes deficient

Lactate

Key features

Confusion, ophthalmoplegia, ataxia; then confabulation and amnesia

Management

IV thiamine BEFORE glucose

Not clinical guidance. Written from standard clinical biochemistry, not from the uploaded documents, and marked unreviewed. Teaching-level reference for study and database seeding only. It must not be used to manage a patient.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Non-Alcoholic Wernicke-Korsakoff Syndrome After a Whipple Procedure: Delayed Recognition, Neuropsychological Findings, and Rehabilitation Follow-Up: A Case Report.

    Demir ÜF, Karakuş Dilbaz F, Memur NB, Keskinkılıç C, Hasanefendioğlu Bayrak A, Battal M. · 2026-09-01

    open access unreviewed
  2. 2
    Wernicke's Encephalopathy Following Semaglutide Treatment for Obesity: A Systematic PRISMA Review of Case-Based Evidence.

    Bidesie J, Oudman E. · 2026-07-03

    cited 1× open access unreviewed
  3. 3
    [Diagnostic challenges of Wernicke-Korsakoff syndrome: A case report].

    Hoppstock P, Sommer L, Jachs M, Dejaco C, Kasprian G, Stepponat R, Trojer A, Weber S, Listabarth S, König D. · 2025-12-16

    unreviewed
  4. 4
    Wernicke's Encephalopathy (WE) Associated with Hyperemesis Gravidarum (HG) Presenting with Psychiatric Morbidity: Description of Two Cases.

    Grover S, Kathiravan S, Kale A, Dua D, Sikka P, Dutta U. · 2024-08-02

    open access unreviewed
  5. 5
    Ophelia Syndrome: Acute Stupor as a Primary Manifestation of Hodgkin Lymphoma Diagnosed by Fluorodeoxyglucose Positron Emission Tomography.

    Cortes Bravo A, Espinoza Rios AY, Bonilla Navarrete AM, Fontecha Delgado CA, Leon Chavez AF, Torres Casas KR. · 2026-08-05

    open access unreviewed
  6. 6
    Worldwide research landscape of psychiatric emergency medicine: A bibliometric review from 2014 to 2023.

    Ekingen E, Ucdal M, Koca E, Baladura S. · 2026-08-01

    open access unreviewed
  7. 7
    A review of the relationship between dimensions of alcohol consumption and the burden of disease: 2026 update including Mendelian randomisation studies.

    Carr S, Espinosa Dice AL, Gmel GE, Hassan AS, Shield KD, Rehm J. · 2026-05-13

    cited 6× open access unreviewed
  8. 8
    Micronutrient deficiencies in hepatic cirrhosis: Navigating challenges to assessment and implications for clinical management: A narrative review.

    Estes-Doetsch H, Wellner M, Ziegler J. · 2026-04-22

    unreviewed
  9. 9
    Non-alcoholic Wernicke-Korsakoff Syndrome: A Narrative Review.

    Batarfi MA. · 2026-07-21

    open access unreviewed
  10. 10
    Alcoholic cirrhosis with Wernicke encephalopathy: Clinical case report.

    Liu H, Cai H, He D. · 2026-07-01

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.