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(acquired B1 deficiency) Acquired unreviewed

Wernicke-Korsakoff syndrome

PDC / TCA / PPP (thiamine) PDH, alpha-KG dehydrogenase, transketolase

Enzyme or protein defect

PDH, alpha-KG dehydrogenase, transketolase

Accumulates or becomes deficient

Lactate

Key features

Confusion, ophthalmoplegia, ataxia; then confabulation and amnesia

Management

IV thiamine BEFORE glucose

Not clinical guidance. Written from standard clinical biochemistry, not from the uploaded documents, and marked unreviewed. Teaching-level reference for study and database seeding only. It must not be used to manage a patient.

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Longitudinal 18F-Fluorodeoxyglucose Positron Emission Tomography (18F-FDG PET) Findings in Korsakoff Syndrome After Rapid Weight Loss During Tirzepatide Therapy: A Case Report.

    Crelier VT, Vidal AS, Rezende NB, Figueiredo MR, de Almeida SA, Jorge JK, de Freitas GR. · 2026-06-02

    unreviewed
  2. 2
    Civil medical liability in general surgery: A systematic review.

    Ketsekioulafis I, Katsos K, Kolentinis C, Sapka T, Spiliopoulou C, Lytras T, Sakelliadis EI, Arkadopoulos N. · 2026-05-13

    open access unreviewed
  3. 3
    Perinatal consumption of a thermally processed diet alters feeding behavior and has sex-dependent effects upon metabolism in later life in mice.

    Lima MTNS, Delayre-Orthez C, Howsam M, Jacolot P, Niquet-Léridon C, Okwieka A, Anton PM, Perot M, Ghinet A, J… · 2026-02-19

    open access unreviewed
  4. 4
    Mediodorsal thalamus of alcohol-dependent mice shows genetic and physiological adaptations and alcohol-biased calcium signaling.

    Martin JC, Reeves KC, Carter KA, Davis M, Schneider A, Meade E, Lebonville CL, Nimitvilai-Roberts S, Hoffman … · 2026-02-16

    unreviewed
  5. 5
    Alcohol-related Wernicke-Korsakoff syndrome in a patient hospitalized for severe mania: A case report highlighting diagnostic and management challenges.

    Sinha N, Khadse PA. · 2026-05-19

    unreviewed
  6. 6
    Dry Beriberi During Pregnancy After Hyperemesis Gravidarum: A Case Report of Axonal Sensorimotor Polyneuropathy.

    Yazough H, Menay H, El Oumri AA. · 2026-05-23

    open access unreviewed
  7. 7
    Steroid-Responsive Encephalopathy Associated With Autoimmune Thyroiditis Presenting As Acute Psychosis: A Diagnostic Pitfall.

    Palacio I, Nedjar OG, Flores Soto NC, Iglesias A, Campuzano Arias S, Surksha MA, Barros M, Ludena A, Angueira… · 2026-05-17

    open access unreviewed
  8. 8
    Differential Effects of Hypoglycemia and Excitotoxic Signals on SN56 Septal Cholinergic Neuronal Cells.

    Gul-Hinc S, Szutowicz A, Ronowska A, Jankowska-Kulawy A. · 2026-05-22

    open access unreviewed
  9. 9
    Early 60-Day Morbidity after Sleeve Gastrectomy Versus One-Anastomosis Gastric Bypass: A Propensity-Matched Single-Center Cohort of 2,382 Patients.

    Guetta O, Vasyliev I, Osyntsov A, Vakhrushev A, Daniel S, Arnon Y, Dukhno O. · 2026-04-15

    open access unreviewed
  10. 10
    A to Z of Health: An Evidence-Based Narrative Review of Multivitamin-Multimineral and Nutraceutical Supplementation.

    Nawathe V, Verma S, Pal A, Pawar D, Sharma A. · 2026-04-30

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.