(acquired B1 deficiency) Acquired unreviewed
Wernicke-Korsakoff syndrome
PDC / TCA / PPP (thiamine)
PDH, alpha-KG dehydrogenase, transketolase
Enzyme or protein defect
PDH, alpha-KG dehydrogenase, transketolase
Accumulates or becomes deficient
Lactate
Key features
Confusion, ophthalmoplegia, ataxia; then confabulation and amnesia
Management
IV thiamine BEFORE glucose
Not clinical guidance. Written from standard clinical biochemistry, not from the uploaded documents, and marked unreviewed. Teaching-level reference for study and database seeding only. It must not be used to manage a patient.
Recent literature
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