Enzyme or protein defect
Unrestrained ketogenesis in insulin deficiency
Accumulates or becomes deficient
Acetoacetate, beta-hydroxybutyrate
Key features
Hyperglycaemia, high anion-gap acidosis, Kussmaul breathing, acetone breath, dehydration
Management
IV fluids, insulin infusion, potassium replacement
Not clinical guidance. Written from standard clinical biochemistry, not from the uploaded documents, and marked unreviewed. Teaching-level reference for study and database seeding only. It must not be used to manage a patient.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Efficacy and safety of SGLT2 inhibitors in elderly patients with type 2 diabetes.
Chuang CS, Kor CT, Wang SY, Hsu YL. · 2026-07-13
unreviewed -
2
Leverage of quick-soluble gelatin microparticles in transarterial chemoembolization of canine urothelial carcinomas.
Jeon S, Lee G, Kim JK, Lee N, Chang D. · 2026-05-29
open access unreviewed -
3
Improving pediatric post-acute kidney injury care: considerations for the clinician.
Golan Lagziel T, Al-Dmour A, Chanchlani R, Robinson CH. · 2026-05-20
open access unreviewed -
4
Tandem extracorporeal blood purification therapies for sepsis and acute kidney injury in critically ill children: a state-of-the-art review.
Shirode P, Sethi SK, Nascimento D, Tanna S, Johnson E, Safadi K, Beck T, Bakkaloglu SA, Kirpalani A, Raimer P… · 2026-04-14
open access unreviewed -
5
Exploring self-care practices, experiences, and interventions among adolescents and young adults with type 1 diabetes in Sub-Saharan Africa: a scoping review protocol.
Wondim D, Keller E, Abebe H, Tiberg I. · 2026-03-17
open access unreviewed -
6
The association between low hemoglobin-to-red blood cell distribution width ratio and macroalbuminuria in diabetic kidney disease: evidence from NHANES and an external validation cohort.
Wang J, Yu L, Yin J, Yin Y, Qi X, Wu Y. · 2026-03-15
open access unreviewed -
7
Management of long COVID-19 in children and adolescents: from diagnosis to therapeutically approaches.
Caliman-Sturdza OA, Gheorghita R, Lobiuc A, Filip R, Soldanescu I, Mangul S, Dimian M. · 2026-03-11
cited 2× open access unreviewed -
8
Real world incidence, predictors and outcomes of endocrine immune-related adverse events following immune checkpoint inhibitors.
Tan S, Wang Y, Cai Y, Guo H, Gao Y. · 2026-03-09
open access unreviewed -
9
Targeting mitochondrial quality control in diabetic kidney disease: emerging therapeutic opportunities.
Luo J, Lu F, Cuciureanu M, Xu X, Dong H, Gong M. · 2026-02-03
cited 2× open access unreviewed -
10
Biochemical phenotypes of acute kidney injury and their association with major adverse kidney events.
Maggiani-Aguilera P, Navarro-Blackaller G, Rodriguez-Peña PA, García-Barrón Y, Saldaña-Rocha E, Gómez JA, Chá… · 2026-01-27
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.