Enzyme or protein defect
Unrestrained ketogenesis in insulin deficiency
Accumulates or becomes deficient
Acetoacetate, beta-hydroxybutyrate
Key features
Hyperglycaemia, high anion-gap acidosis, Kussmaul breathing, acetone breath, dehydration
Management
IV fluids, insulin infusion, potassium replacement
Not clinical guidance. Written from standard clinical biochemistry, not from the uploaded documents, and marked unreviewed. Teaching-level reference for study and database seeding only. It must not be used to manage a patient.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Outcomes of pediatric urgent-start peritoneal dialysis: a single-center experience from Jordan.
Al Qaoud D, Haifawi A, Al-Qaoud W, Al-Ma'aiteh A, Kufoof T, Alrashaideh MR, Abdelfattah AS, Al-Husari M, Al M… · 2026-09-21
open access unreviewed -
2
Indirect traumatic optic neuropathy in a high-risk diabetic adolescent: A rare clinical presentation.
El Azzouzi R, Boukhlouf O, Dani B, Boulaadas M. · 2026-09-02
open access unreviewed -
3
Development and validation of a nomogram to predict 28-day all-cause mortality in sepsis patients complicated by acute kidney injury.
Jiang L, Li L, Xu Y, Liu J, Ding W, Liu J, Yin D, Ou S, Wen L. · 2026-08-24
open access unreviewed -
4
A study on risk factors for the progression from T2DM to end-stage renal disease based on Mendelian randomization and logistic regression analysis.
Wang Y, Guo X, Li Y, Fu Q, Zhang C, Bai S. · 2026-08-05
open access unreviewed -
5
Efficacy and safety of SGLT2 inhibitors in elderly patients with type 2 diabetes.
Chuang CS, Kor CT, Wang SY, Hsu YL. · 2026-07-13
open access unreviewed -
6
Management of pneumonia by the emergency radiologist.
Plasencia-Martínez JM, Bravo-Urbieta J, Blanco-Barrio A. · 2026-07-03
open access unreviewed -
7
A phase 3, randomized study to evaluate the safety, tolerability, and immunogenicity of V116 in children and adolescents with increased risk of pneumococcal disease (STRIDE-13).
Jagannath V, Pathirana J, Perez Yepes CA, Lopez-Medina E, Navarro JA, Korbal P, Phongsamart W, Inui A, Kantel… · 2026-06-23
cited 3× open access unreviewed -
8
Leverage of quick-soluble gelatin microparticles in transarterial chemoembolization of canine urothelial carcinomas.
Jeon S, Lee G, Kim JK, Lee N, Chang D. · 2026-05-29
open access unreviewed -
9
Improving pediatric post-acute kidney injury care: considerations for the clinician.
Golan Lagziel T, Al-Dmour A, Chanchlani R, Robinson CH. · 2026-05-20
open access unreviewed -
10
Tandem extracorporeal blood purification therapies for sepsis and acute kidney injury in critically ill children: a state-of-the-art review.
Shirode P, Sethi SK, Nascimento D, Tanna S, Johnson E, Safadi K, Beck T, Bakkaloglu SA, Kirpalani A, Raimer P… · 2026-04-14
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.