Enzyme or protein defect
Unrestrained ketogenesis in insulin deficiency
Accumulates or becomes deficient
Acetoacetate, beta-hydroxybutyrate
Key features
Hyperglycaemia, high anion-gap acidosis, Kussmaul breathing, acetone breath, dehydration
Management
IV fluids, insulin infusion, potassium replacement
Not clinical guidance. Written from standard clinical biochemistry, not from the uploaded documents, and marked unreviewed. Teaching-level reference for study and database seeding only. It must not be used to manage a patient.
Recent literature
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