Cyanide / carbon monoxide poisoning
Enzyme or protein defect
Complex IV (cytochrome c oxidase) inhibition
Accumulates or becomes deficient
Lactate; high venous O2 (cyanide)
Key features
Headache, coma, lactic acidosis; cherry-red skin in CO; bitter-almond odour in cyanide
Management
Hydroxocobalamin/nitrites + thiosulfate; 100% O2 or hyperbaric for CO
Not clinical guidance. Written from standard clinical biochemistry, not from the uploaded documents, and marked unreviewed. Teaching-level reference for study and database seeding only. It must not be used to manage a patient.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Addressing Cognitive Biases in Interpreting an Elevated Lactate in a Patient with Type 1 Diabetes and Thiamine Deficiency.
Chehayeb RJ, Ilagan-Ying YC, Sankey C. · 2023-02-22
cited 2× open access unreviewed -
2
Brain Imaging in New Onset Psychiatric Presentations.
Baroud E, Hourani R, Talih F. · 2019-01-01
unreviewed -
3
Measurement of Mitochondrial Respiration and Motility in Acute Care: Sepsis, Trauma, and Poisoning.
Jang DH, Greenwood JC, Spyres MB, Eckmann DM. · 2016-07-21
cited 51× unreviewed -
4
Etiology and therapeutic approach to elevated lactate levels.
Andersen LW, Mackenhauer J, Roberts JC, Berg KM, Cocchi MN, Donnino MW. · 2013-10-01
cited 462× unreviewed -
5
Comparative polarized-light and electron microscopic studies of changes in the structure of the intercalate disc following various experimental lesions.
Somogyi E, Sótonyi P, Balogh I, Nemes A, Rubányi G. · 1978-01-01
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.