Enzyme or protein defect
Overproduction or underexcretion of urate
Accumulates or becomes deficient
Monosodium urate crystals
Key features
Acute podagra; negatively birefringent needle-shaped crystals; tophi
Management
NSAIDs/colchicine/steroids acutely; allopurinol or febuxostat long term
Not clinical guidance. Written from standard clinical biochemistry, not from the uploaded documents, and marked unreviewed. Teaching-level reference for study and database seeding only. It must not be used to manage a patient.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Male reproductive surgeries and long-term kidney outcomes: a Mendelian randomization and meta-analysis of UK Biobank and FinnGen.
Zeng D, Zhu L, Shi L, Wang Y, Liu J, Peng Y, Zhao X, Wang Y, Sun L, He H. · 2026-08-04
unreviewed -
2
Type III intermediate filaments as novel CoAlation targets.
Goya-Iglesias N, Yu BYK, Gout I, Pérez-Sala D. · 2026-06-24
unreviewed -
3
Nephrotoxic medication burden and drug-related problems in patients with chronic kidney disease using SGLT2 inhibitors.
Ozturk Yalcin Z, Erdut A, Haberal G, Arici M, Bayraktar-Ekincioglu A. · 2026-06-23
open access unreviewed -
4
Multi-trajectories of serum uric acid/high density lipoprotein cholesterol ratio and fasting plasma glucose in chronic kidney disease.
Xie M, Luo Z, Xiong H, Jiang J, Liu Y, Guo S, Yao X, Wan Z, Zhang J, Shuai P. · 2026-06-18
open access unreviewed -
5
Uric acid alleviates the inflammatory response in LPS-induced BV2 cells and MPTP-induced PD mice by resisting ferroptosis through the Nrf2 signalling pathway.
Zhou D, Xiong T, Yang B, Liu F, Mo X, Chen T, Lu P, Liang X, Li L, Qin Y, Lu D, Huang F, Yang X. · 2026-06-04
open access unreviewed -
6
Polydatin alleviates adenine-induced nephropathy in mice.
Sheng T, Ma T, Jin X, Chen D, Che S, Wang J, Shen J, Shi C, Li Q, Sun Y, Chen D, Xu G. · 2026-05-31
open access unreviewed -
7
A treat-to-target urate management strategy does not improve kidney outcome in patients with chronic kidney disease and asymptomatic hyperuricemia: a target trial emulation.
Liu Q, Hu Y, He R, Fang Z, He W, Zheng D, Jin J, He Q. · 2026-05-07
cited 1× open access unreviewed -
8
Impact of infrared moxibustion for patients with mild hyperlipidemia: a protocol for a randomized controlled trial.
Xie H, Feng F, Zhu J, Zhu W, Xiong S, Xing B, Chen S, Li Q, Zhu T, Liu M. · 2026-05-04
cited 1× open access unreviewed -
9
Deciphering the interplay between serum urate and bone mineral density: insights from observational and genetic perspectives.
Xiang R, Zhong Y, Zhao X, Deng Q, Hou J, Sha L, Qu Y, Tang M, Zhu J, Zheng S, Han T, Zhou J, Yu T, Yang B, So… · 2026-04-22
open access unreviewed -
10
Decoding the renal-cochlear axis: explainable machine learning and phenotype clustering reveal high-risk hearing loss subtypes in CKD.
Chen L, Wang J, Liu G, Zhao Y, Zhou Z, Li Q. · 2026-04-21
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.