Enzyme or protein defect
Overproduction or underexcretion of urate
Accumulates or becomes deficient
Monosodium urate crystals
Key features
Acute podagra; negatively birefringent needle-shaped crystals; tophi
Management
NSAIDs/colchicine/steroids acutely; allopurinol or febuxostat long term
Not clinical guidance. Written from standard clinical biochemistry, not from the uploaded documents, and marked unreviewed. Teaching-level reference for study and database seeding only. It must not be used to manage a patient.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Advances and perspectives in genetically encoded biosensors for biomarker detection and theranostic circuits.
Xu J, Qi Q, Wang Q. · 2026-09-23
open access unreviewed -
2
Harnessing gasotransmitters for orthopaedic infection therapy: Mechanisms and advanced delivery platforms.
Zhang JY, Yang YQ, Zhang ZX, Jin JL, Luo ZY, Wang DY, Ruan CX, Dai TZ, Huang YL, Xu J, Shi JW, Li JY, Lei PF. · 2026-09-03
open access unreviewed -
3
High-level amyrin production in <i>Yarrowia lipolytica</i> via metabolic and enzyme engineering.
Elsharawy H, Abdullah CN, Yin X, Zhou J. · 2026-07-15
open access unreviewed -
4
A decade iterative development of MOF-based uric acid luminescent sensors (2016-2026): From design strategy, mechanistic insights to portable detection.
Wang J, Wang H, Zhang M, Chen Y, Zhang C, Zhao Y, Gao Y, Fan L. · 2026-07-10
unreviewed -
5
Comparative efficacy of ultrasound-guided intra-articular injection of platelet-rich plasma (PRP), hydrolyzed type I collagen, and hyaluronic acid in patients with knee osteoarthritis: a randomized controlled trial.
Raeissadat SA, Mousavikhah SE, Nazari Nodoushan A, Mahdi Kaghazi AH, Khavari Ardestani D, Rahmani F, Layegh H. · 2026-09-25
open access unreviewed -
6
Patient and healthcare professional perceptions of weight reduction in the treatment of knee osteoarthritis: A systematic literature review.
Conaghan PG, Rolland C, Frampton J, Lavoie L, Giblin K, Robinson R, Perez-Nieves M. · 2026-09-07
open access unreviewed -
7
Gut microbiota-mediated uric acid metabolism: Novel insights for developing urate-lowering and anti-gout medications.
Jiang Y, Shi X, Yang Q, Pang J, Zhan P, Xu S, Wu T. · 2026-09-01
unreviewed -
8
Care of incontinence-associated dermatitis in older adults: A randomized controlled trial comparing zinc oxide-petroleum jelly and centella asiatica-aloe vera preparations.
Chaisomsee S, Banharak S, Sommana C, Tuntiyasawasdikul S, Sim-Im S, Ransinyo K, Limpawattana P, Deesui W, Pim… · 2026-08-20
open access unreviewed -
9
Integrated transcriptomics and metabolomics reveal suppression of the PPAR α/γ pathway linking purine metabolism disorder to high-protein diet-induced hyperuricemia in goslings.
Li X, Xie Y, Zhang M, Zou T, Zhong C, Rajput ZI, Bi S, Cao L. · 2026-08-04
open access unreviewed -
10
Comprehensive trends in Chronic Kidney Disease prevalence and comorbidities across eGFR and albuminuria categories: a 20-year analysis of NHANES data.
Farag YM, Zheng Z, Dar AH, Tariq A. · 2026-09-14
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.