Enzyme or protein defect
Overproduction or underexcretion of urate
Accumulates or becomes deficient
Monosodium urate crystals
Key features
Acute podagra; negatively birefringent needle-shaped crystals; tophi
Management
NSAIDs/colchicine/steroids acutely; allopurinol or febuxostat long term
Not clinical guidance. Written from standard clinical biochemistry, not from the uploaded documents, and marked unreviewed. Teaching-level reference for study and database seeding only. It must not be used to manage a patient.
Recent literature
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