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ABCC2 AR unreviewed

Dubin-Johnson syndrome

Bilirubin excretion

Enzyme or protein defect

MRP2 canalicular transporter

Accumulates or becomes deficient

Conjugated bilirubin

Key features

Conjugated hyperbilirubinaemia; grossly black liver

Management

Benign; reassurance

Not clinical guidance. Written from standard clinical biochemistry, not from the uploaded documents, and marked unreviewed. Teaching-level reference for study and database seeding only. It must not be used to manage a patient.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    [Analysis a patient with Dubin-Johnson syndrome due to a rare c.4120C>T nonsense variant of ABCC2 gene].

    Xiao L, Zhu X, Dou R, Huang A, Yang Y. · 2026-10-01

    unreviewed
  2. 2
    Endogenous Biomarkers to Evaluate Transporter-Mediated Drug-Drug Interactions: Current Evidence, Impact on Clinical Pharmacology Strategy, Remaining Gaps, and Future Directions.

    Russell LE, Huang F, Cheung KWK, Varma MVS, Panduga V. · 2026-09-01

    unreviewed
  3. 3
    Use of percutaneous cholecysto-cholangiogram in the evaluation of neonatal cholestasis.

    Spector PR, Tassarotti M, Kim E, Martinez M, Tulin-Silver S. · 2026-06-16

    cited 1× unreviewed
  4. 4
    Clinical Outcomes of a Multi-Ingredient <i>Coriolus versicolor</i>-Based Vaginal Gel in Greek Women with Low-Grade Cervical Lesions: The PAPILOBS-GR Real-Life Prospective Study.

    Michail G, Daponte A, Valasoulis G, Dinas K, Bilirakis E, Pappa K, Chronopoulos K, Akrivis C, Anastasiadi Z, … · 2026-08-25

    open access unreviewed
  5. 5
    A Rare Diagnosis of Dubin-Johnson Syndrome During Pregnancy: A Case Report.

    Mousavi SRM, Pourhasan F, Simab PA, Beikmohammadi-Gharehsaghghal S, Kaini-Shamsabadi D, Karimzadeh-Soureshjan… · 2026-08-06

    open access unreviewed
  6. 6
    Resolving a Complex Neonatal Phenotype by Rapid Trio Whole-Genome Sequencing: A De Novo 11q14.3-q22.3 Deletion and a Splicing-Altering Synonymous ANK1 Variant.

    Lee HW, Jang JH, Lee BH, Youk HJ, Kim ES, Cho KH, Chang YS, Jo HS, Jang MA. · 2026-06-18

    open access unreviewed
  7. 7
    Use of Next-Generation Sequencing and Whole-Exome Sequencing in the Diagnosis of Adult-Onset Familial Intrahepatic Cholestasis: Challenges in Interpreting Variants of Uncertain Significance.

    Conti A, Gabrielli F, Ferrari S, Vaisfeld A, De Masi C, Azzaroli F, Piscaglia F, Vitale G. · 2026-07-25

    open access unreviewed
  8. 8
    Ileal Bile Acid Transporter Inhibitors for Symptomatic Cholestasis due to Vanishing Bile Duct Syndrome in Adults.

    Vignone A, Montecalvo D, Ferrari P, Nardelli S, Di Cola S, D'Amati G, Ascione A, Ginanni Corradini S, Parisse… · 2026-06-18

    open access unreviewed
  9. 9
    ABCC2 mutation spectrum and phenotypic diversity in pediatric Dubin-Johnson syndrome: a chinese cohort analysis.

    Wang M, Yuan W, Li J, Bi Z, Qiao C, Jiang H, Li J. · 2026-05-14

    unreviewed
  10. 10
    Carrier screening in the reproductive setting-Are there medical implications for the heterozygote?-A guide for clinicians.

    Rosenfeld EB, Kasatkin N, Yu BL, Velinov M, Brandt JS, Ashkinadze E. · 2026-04-09

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.