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UROD AD / acquired unreviewed

Porphyria cutanea tarda

Heme synthesis

Enzyme or protein defect

Uroporphyrinogen decarboxylase

Accumulates or becomes deficient

Uroporphyrin

Key features

Commonest porphyria; blistering photosensitivity, hypertrichosis, tea-coloured urine; linked to HCV, alcohol, iron, oestrogen

Management

Phlebotomy, low-dose hydroxychloroquine, trigger avoidance

Not clinical guidance. Written from standard clinical biochemistry, not from the uploaded documents, and marked unreviewed. Teaching-level reference for study and database seeding only. It must not be used to manage a patient.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    The ketogenic diet is not for everyone: contraindications, side effects, and drug interactions.

    Dyńka D, Rodzeń Ł, Rodzeń M, Łojko D, Karakuła-Juchnowicz H, Ede G, Grzywacz Ż, Antosik K, Sethi S, Unwin D. · 2026-01-04

    cited 4× open access unreviewed
  2. 2
    [Cutaneous presentation of digestive tract disorders and liver disease].

    Sticherling M. · 2026-08-05

    unreviewed
  3. 3
    Understanding the Clinical Spectrum of the Cutaneous and Acute Hepatic Porphyrias.

    Vu TN, Talasila S, Jeha GM, Nadir U, Mohammad TF, Lim HW, Abraham I, Grove D, Tolkachjov SN. · 2026-05-29

    unreviewed
  4. 4
    Updates to gene-disease classifications and inheritance patterns for porphyrias.

    Reeves EB, Hankey W, Clair PS, Goldstein JL, Wilke MVMB, Feigenbaum A, Hung C, Spector E, Craigen WJ. · 2026-04-30

    unreviewed
  5. 5
    Clostridial necrotizing infection with multiorgan failure in an unhoused patient following a presumed spider bite.

    Vo LN, Lam LD, Naganawa S, Ghasemiesfe A. · 2026-06-21

    open access unreviewed
  6. 6
    Homozygous variegate porphyria: Two cases misdiagnosed as erythropoietic protoporphyria.

    Wang C, Bensaber N, Rebeiz L, Tran B, Tortorelli S, Kyle K, Yalom LK, Moghe A, Anderson KE, Leaf RK, Yeung AK. · 2026-06-07

    open access unreviewed
  7. 7
    Novel PPOX Mutation With Ocular Involvement in Variegate Porphyria: Case Report and Literature Review.

    Ramos-Dávila EM, Sayegh Y, Ebehart CG, Thorne JE, Liberman P. · 2026-06-12

    unreviewed
  8. 8
    When the Skin Tells Another Story: Incidental Epidermolysis Bullosa in an Adult Hospitalized for Chronic Respiratory Symptoms.

    Acosta García E, Castillo Martínez J, Carranza Ambriz KP, Maya Talamantes E, Lozano Aguilar M. · 2026-06-04

    open access unreviewed
  9. 9
    Monogenic Syndromes as a Cause of Adverse Drug Reactions in the Russian Population.

    Buianova AA, Cheranev VV, Shmitko AO, Vasiliadis IA, Samitova AF, Suchalko ON, Repinskaia ZA, Kuznetsov MI, B… · 2026-05-28

    open access unreviewed
  10. 10
    Severe Phototoxic Vesiculobullous Eruption Following Sequential Exposure to Terbinafine, Ciprofloxacin, and Trimethoprim-Sulfamethoxazole.

    Gonzalez Alvarez RR. · 2026-05-26

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.